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Custom LLMs for 20% Higher Clinical Trial Patient Retention

A detailed exploration of Techdome’s custom LLM implementation that streamlines clinical trial processes, and the decisions that made it possible.

Rahul Joshi
CEO at Techdome
Gaurav Chouhan
CTO at Techdome
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Format
PDF
Page Count
33
Published
June 23, 2025
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Custom LLMs for 20% Higher Clinical Trial Patient Retention

A detailed exploration of Techdome’s custom LLM implementation that streamlines clinical trial processes, and the decisions that made it possible.

This report emphasizes the practical mechanics of scalable automation – covering model specialization, data structuring, system modularity, and human-in-the-loop feedback.

For product and engineering leaders in mid-sized to large organizations operating in data-intensive, high-stakes workflows –particularly in life sciences, healthcare tech, or other sectors with complex process automation needs – it serves as a technically detailed case study in moving from experimentation to production-grade deployment.

Key decisions
  • Custom LLM + traditional ML interplay with structured handoff
  • Clinician and patient feedback used for RLHF and domain finetuning
  • Key-attribute mapping to enable cross-industry portability
  • Real-time predictive validation at point-of-entry
  • Multi-layer flagging for compliance and error handling
Key results
  • 20% increase in patient engagement and retention
  • 95% decrease in manual data entry errors and inconsistencies
  • 25% faster time-to-market
  • Trial success rate increased from 45% to 65%
  • A 4/5 CSAT score, from 1,000 trial participants

1. The Clinical Trial Problem

The challenges Techdome set out to address, segregated into sponsor-side and systemic.

2. Techdome’s Solution

An overview of the solution Techdome built: features, architecture, zero-trust security, and monitoring and logging.

3. Preparing High Quality Clinical Data

Rahul and Gaurav’s approach to the foundational task of data preparation, including deciding how to structure the data.

4. LLM Customization Techniques

How the LLMs were adapted to the specific use case of clinical trials, including a detailed workflow diagram.

5. Predictive Modeling

The predictive modeling capabilities of the solution, including matching candidates to trials and data validation.

6. Infrastructure

An in-depth look at architectural decisions, including hosted GPUs, the three pillars of Techdome’s design philosophy, and the tech stack.

7. Performance Metrics and Results

Techdome’s solution in perspective.

8. Future Directions

Techdome’s next steps, and some discussion on the future of clinical trial automation.

9. Conclusion and Key Takeaways for Tech Leaders

A combination of Rahul’s, Gaurav’s, and TechLeader’s key takeaways from this report.

"The current industry challenge is that most AI work revolves around proofs of concept that never see the light of day. Few people understand how to take AI solutions from concept to production."

Gaurav Chouhan, CTO at Techdome

Meet the Experts

Rahul Joshi

CEO at Techdome
Rahul Joshi is CEO and co-founder of Techdome Group. He brings extensive experience from prestigious consulting firms including Deloitte and EPAM Systems, where he led digital transformation projects for Fortune 500 enterprises. Together with his co-founder Gaurav, he focuses on integrating cutting-edge AI automation, enabling both startups and enterprises to leverage technology-driven solutions that transform operations and drive sustainable growth across aviation, manufacturing, insurance, finance, and hospitality.
Other ECHO Reports

Gaurav Chouhan

CTO at Techdome
Gaurav Chouhan is CTO and co-founder of Techdome Group. He brings deep technical expertise in product envisioning, data science, genAI, and scalable cloud architecture, having helped businesses secure over $10 million+ in funding while optimizing enterprise workflows. Together with his co-founder Rahul, he focuses on integrating cutting-edge AI automation, enabling both startups and enterprises to leverage technology-driven solutions that transform operations and drive sustainable growth across aviation, manufacturing, insurance, finance, and hospitality.
Other ECHO Reports

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